Ubd CLIA Kit for Mouse(Mus musculus) | EIAab.comUbd CLIA Kit for Mouse(Mus musculus)

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Ubd (Gene name),

Ubiquitin D (Protein name ), UBD_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ubd(Fat10);

Protein name:

Ubiquitin D;

Alternative:

Ubiquitin-like protein FAT10;Diubiquitin;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interact directly with the 26S proteasome. The interaction with NUB1L vie the N-terminal ubiquitin domain facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own degradation and that of its conjugates (By similarity). Interacts with the spindle checkpoint protein MAD2L1 during mitosis. Present in aggresomes of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions. Forms a thioester with UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg).

Function:

Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases.

Subcellular Location:

Nucleus Cytoplasm Accumulates in aggresomes under proteasome inhibition conditions.

Protein Attributes:

Sequence length:

162

Sequence:

50:

100:

150:

162:

SLLFLTTHCT | GG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.140210

KEGG:

mmu:24108

String:

P63072

STRING:

10090.ENSMUSP00000035808

SMR:

P63072

Pfam:

PF00240

Uniprot:

P63072

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ELISA Kit for Mouse Ubiquitin D

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E1744h

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96T

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ELISA Kit for Mouse Ubiquitin D

Cat.:

E1744m

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96T

ELISA Kit for Mouse Ubiquitin D

Cat.:

E1744r

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96T

CLIA Kit for Mouse Ubiquitin D

Cat.:

U1744m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Ubiquitin D

Cat.:

U1744r

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Packing:

96T

CLIA Kit for Mouse Ubiquitin D

Cat.:

U1744h

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96T

Polyclonal Antibody for Mouse Ubiquitin D

Cat.:

P1744Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Ubiquitin D

Cat.:

P1744Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Ubiquitin D

Cat.:

P1744Rb-m

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40ug/0.2ml

Monoclonal Antibody for Mouse Ubiquitin D

Protein for Mouse Ubiquitin D

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Disruption of the mouse Fat10 gene by gene targeting in the mouse embryonic stem cells."
Yu X. , Liu Y. , Weissman S.M.
Submitted (2000-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Small intestine.
3.

"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
Ebert L. , Muenstermann E. , Schatten R. , Henze S. , Bohn E. , Mollenhauer J. , Wiemann S. , Schick M. , Korn B.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Mammary gland.
6.

"The ubiquitin-like protein FAT10 forms covalent conjugates and induces apoptosis."
Raasi S. , Schmidtke G. , Groettrup M.
J. Biol. Chem.276:35334-35343(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INDUCTION;MUTAGENESIS OF 161-GLY-GLY-162
7.

"FAT10, a ubiquitin-independent signal for proteasomal degradation."
Hipp M.S. , Kalveram B. , Raasi S. , Groettrup M. , Schmidtke G.
Mol. Cell. Biol.25:3483-3491(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease."
Ross M.J. , Wosnitzer M.S. , Ross M.D. , Granelli B. , Gusella G.L. , Husain M. , Kaufman L. , Vasievich M. , D'Agati V.D. , Wilson P.D. , Klotman M.E. , Klotman P.E.
J. Am. Soc. Nephrol.17:996-1004(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"FAT10/diubiquitin-like protein-deficient mice exhibit minimal phenotypic differences."
Canaan A. , Yu X. , Booth C.J. , Lian J. , Lazar I. , Gamfi S.L. , Castille K. , Kohya N. , Nakayama Y. , Liu Y.-C. , Eynon E. , Flavell R. , Weissman S.M.
Mol. Cell. Biol.26:5180-5189(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY TNFA AND IFNG;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
10.

"E1-L2 activates both ubiquitin and FAT10."
Chiu Y.-H. , Sun Q. , Chen Z.J.
Mol. Cell27:1014-1023(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBA6
11.

"Fat10 is an epigenetic marker for liver preneoplasia in a drug-primed mouse model of tumorigenesis."
Oliva J. , Bardag-Gorce F. , French B.A. , Li J. , McPhaul L. , Amidi F. , Dedes J. , Habibi A. , Nguyen S. , French S.W.
Exp. Mol. Pathol.84:102-112(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY DRUG INJURY
12.

"The ubiquitin-like protein FAT10 mediates NF-kappa-B activation."
Gong P. , Canaan A. , Wang B. , Leventhal J. , Snyder A. , Nair V. , Cohen C.D. , Kretzler M. , D'Agati V. , Weissman S. , Ross M.J.
J. Am. Soc. Nephrol.21:316-326(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE

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